Ensayo en embriones bovinos (BEA)

Next Generation Embryotoxicity Testing

Bovine-based
More predictive
More ethical
  • 100+ embryos tested per assay
  • Biological validation beyond conventional QC testing

The challenge

The world needs a better standard

All culture media, consumables, and
devices used in ART must pass
embryotoxicity testing before reaching patients.
For decades, the Mouse Embryo
Assay (MEA) has been the default — yet it relies on thousands of purpose-bred animals and faces well-documented reproducibility concerns.


Bovine Embryo Assay (BEA) addresses these limitations by using oocytes sourced from animals within the food production chain, all subject to rigorous veterinary inspection and full traceability,
ensuring the highest standards of quality and safety.

Parameter MEA BEA
Sensitivity to toxic compounds Vitrification
Human physiology relevance
No purpose-bred animals
Unlimited biological supply
Reduced environmental impact
Multiple endpoints assessed
  • = Meets criterion
  • = Partially meets criterion
  • = Does not meet criterion

Our Offerings

Tailored assays for every need

BEA — Standard

From 10 days
Full in vitro production (maturation + fertilisation). Evaluates cleavage rate, blastocyst rate (D7–D8), developmental kinetics, and mean cell count per blastocyst. Min. 100 zygotes/device.
Enhanced

BEA-PLUS — Differential Staining

From 15 days
D8 blastocysts stained to distinguish Inner Cell Mass (ICM) from Trophectoderm (TE), providing deeper insight into embryo quality. Min. 100 zygotes/device.

BEA-VITRI — Vitrification

From 20 days
D7 blastocysts vitrified and warmed after one week. Survival rate and total cell count assessed 24 h post-warming. Min. 10 vitrified–warmed blastocysts/device.
Turnaround: 10 business days (BEA) to 20 business days
(BEA–VITRI). Custom assay designs available on request.
≥100
Zygotes per device
6+
Endpoints measured
10d
Fastest turnaround

Sobre Nosotros

Science-driven.
Ethics-led.

EmbryoCloud is a specialist
laboratory dedicated to advancing
embryo science in veterinary and
human assisted reproductive
technologies. We combine state-ofthe-
art infrastructure with deep
expertise in bovine in vitro embryo
production to deliver precise,
reproducible, and ethical quality
control.

How it works

  • Sample submission

  • In vitro one-cell embryo production

  • Embryo exposure & monitoring

  • Full report delivered

We test medical devices

Oils & lubricants
Culture media
Plasticware
Incubator surfaces
Custom materials
Catheters
Syringes & tubing

Standardised protocols · Validated
endpoints · Expert interpretation
Results suitable for regulatory quality
control submissions in ART product
development.

Why it matters

3RS: Replacement · Reduction · Refinement

BEA eliminates the need to breed
and sacrifice mice for routine QC
testing. Biological material is sourced
from abattoir by-products — turning
unavoidable waste into scientific
value.

ENDPOINTS ASSESSED BY BEA

  • Cleavage rate
  • Blastocyst rate (Day 7 & 8)
  • Developmental kinetics
  • Mean cell number per blastocyst
  • ICM / Trophectoderm ratio
  • (BEA-PLUS)
  • Warming survival (BEA-VITRI)
Every component entering an IVF laboratory can influence embryo development. Embryotoxicity testing is not a formality — it is the final safeguard for patients.

Proven science
High Sensitivity
No sacrifice

ISO 17025 IN PROGRESS

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